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Rafael Bruschweiler

Rafael Bruschweiler

Professor
Associate Director for Biophysics
CIMAR, NMR

Email: 
Phone: 850 - 644-1768
Fax: 850 - 644-8281
Address: B234 NHMFL
DIT 217 Dittmer Laboratory, Room 217
Tallahassee, FL 32306-4390

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Awards, Honors & Service:
American Physical Society Fellow (2008)
Laukien Prize in NMR Spectroscopy (co-winner) (2006)

Disclaimer: The information presented below was automatically generated from a database. In the rare instance of an exact name match, it is possible that a citation is inaccurately attributed. The listing should therefore be considered unofficial. To report a mismatched publication, contact IMsystems@magnet.fsu.edu

2009 Publications & Scientific Activities

    Peer-Reviewed Publications
  • Kaplan, F.; Badri, D.V.; Zachriah, C.; Ajredini, R.; Sandoval, F.J.; Roje, S.; Levine, L.H.; Zhang, F.; Robinette, S.L.; Alborn, H.T.; Zhao, W.; Stadler, M.; Nimalendran, R.; Dossey, A.T.; Bruschweiler, R.A.; Vivanco, J.M. and Edison, A.S., Bacterial Attraction and Quorum Sensing Inhibition in Caenorhabditis elegans Exudates, Chem. Ecol., 35, 878-892 (2009)

2008 Publications & Scientific Activities

    Peer-Reviewed Publications
  • Hus, J.C.; Salmon, L.; Bouvignies, G.; Lotze, J.; Blackledge, M. and Bruschweiler, R., 16-Fold Degeneracy of Peptide Plane Orientations from Residual Dipolar Couplings: Analytical Treatment and Implications for Protein Structure Determination, J. Am. Chem. Soc., 130, 15927-15937 (2008) [read online]
  • Johnson, E.; Bruschweiler-Li, L.; Showatlter, S.A.; Vuister, G.W.; Zhang, F. and Bruschweiler, R., Structure and dynamics of Ca2+-binding domain 1 of the Na+/Ca2+ exchanger in the presence and in the absence of Ca2+, J. Mol. Biol., 377, 945-955 (2008) [read online]
  • Johnson, E.; Showalter, S.A. and Bruschweiler, R., A Multifaceted Approach to the Interpretation of NMR Order Parameters: A Case Study of a Dynamic alpha-Helix, J. Phys. Chem. B, 112, 6203-6210 (2008) [read online]
  • Lakomek, N.A.; Walter, K.F.; Farès, C.; Lange, O.F.; de Groot, B.L.; Grubmüller, H.; Bruschweiler, R.; Munk, A.; Becker, S.; Meiler, J. and Griesinger, C., Self-consistent residual dipolar coupling based model-free analysis for the robust determination of nanosecond to microsecond protein dynamics, J. Biomol. NMR, 41, 139 (2008) [read online]
  • Robinette, S.L.; Zhang, F.; Bruschweiler-Li, L. and Bruschweiler, R., Web Server Based Complex Mixture Analysis by NMR, Anal. Chem., 80, 3606-3611 (2008) [read online]
  • Showalter, S.A.; Bruschweiler-Li, L.; Johnson, E.; Zhang, F. and Bruschweiler, R., Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft, J. Am. Chem. Soc., 130, 6472-6478 (2008) [read online]
  • Snyder, D.A.; Ghosh, A.; Zhang, F.; Szyperski, T. and Bruschweiler, R., Z-matrix formalism for quantitative noise assessment of covariance nuclear magnetic resonance spectra, J. Chem. Phys., 129 (10), 104511 (2008) [read online]
  • Snyder, D.A.; Zhang, F.; Robinette, S.L.; Bruschweiler-Li, L. and Bruschweiler, R., Non-negative matrix factorization of two-dimensional NMR spectra: application to complex mixture analysis, J. Chem. Phys., 128, 052312 (2008) [read online]
  • Zhang, F.; Bruschweiler-Li, L.; Robinette, S.L. and Bruschweiler, R., Self-consistent metabolic mixture analysis by heteronuclear NMR. Application to a human cancer cell line, Anal. Chem., 80 (19), 7549-7553 (2008) [read online]
    Presentations, Posters & Abstracts
  • Bruschweiler-Li, L.; Zhang, F.; Robinette, S.L. and Brüschweiler, R., Webportal for the Processing and Analysis of 2D NMR Data of Metabolomics Samples, Int. Conf. of Magnetic Resonance in Biological Systems (ICMRBS) 23rd Annual Meeting, San Diego, CA, August 24-29 (2008)
  • Bruschweiler-Li, L.; Zhang, F.; Robinette, S.L.; Snyder, D.A. and Brüschweiler, R., Metabolomics strategies by homo- and heteronuclear NMR, Gordon Research Conference: Computational Aspects-Biomolecular NMR, II Ciocco, Italy, May 18-23 (2008)
  • Robinette, S.L.; Zhang F.; Bruschweiler-Li, L. and Brüschweiler, R., Automated Profiling of Metabolomic Mixtures by NMR Spectral Tocsy Traces, NHMFL, REU student poster, Tallahassee, FL, July (2008)
  • Showalter, S.A.; Bruschweiler-Li, L.; Zhang, F. and Brüschweiler, R., Dynamic control of lignad binding modes of the p53-binding cleft in MDM2, Gordon Research Conf. -- Computational Aspects-Biomolecular NMR, II Ciocco, Italy, May 18-23 (2008)
  • Snyder, D.; Zhang, F.; Xu, Y.; Yang, D.W.; Bruschweiler-Li, L. and Brüschweiler, R., Extending the reach of covariance NMR and the factorization of NMR spectra, Gordon Research Conference -- Computational Aspects-Biomolecular NMR, II Ciocco, Italy, May 18-23 (2008)
  • Zhang, F.; Robinette, S.L.; Dossey, A.T. Zachariah, C.; Bruschweiler-Li, L.; Edison, A.S. and Brüschweiler, R., Covariance NMR Metabolomics Web Portal, 49th ENC Conf., Asilomar, CA, March 9-14 (2008)

2007 Publications & Scientific Activities

    Peer-Reviewed Publications
  • Chen, Y.; Zhang, F. and Bruschweiler, R., Residual water suppression by indirect covariance NMR, Magnet. Reson. Chem., 45 (11), 925-8 (2007) [read online]
  • Chen, Y.B.; Zhang, F; Snyder, D.; Gan, Z.H.; Bruschweiler-Li, L. and Bruschweiler, R., Quantitative covariance NMR by regularization, J. Biomol. NMR, 38, 73-77 (2007) [read online]
  • Li, D.-W.; Khanlarzadeh, M.; Wang, J.; Huo, S. and Bruschweiler, R., Evaluation of configurational entropy methods from peptide folding-unfolding simulation, J. Phys. Chem. B, 111, 13807-13813 (2007) [read online]
  • Showalter, S.A. and Bruschweiler, R., Quantitative molecular ensemble interpretation of NMR dipolar couplings without restraints, J. Am. Chem. Soc., 129, 4158-4159 (2007) [read online]
  • Showalter, S.A. and Bruschweiler, R., Validation of molecular dynamics simulations of biomolecules using NMR spin relaxation as benchmarks: application to the AMBER99SB force field, J. Chem. Theory Comput., 3, 961-975 (2007) [read online]
  • Showalter, S.A.; Johnson, E.; Rance, M. and Bruschweiler, R., Toward quantitative interpretation of methyl side-chain dynamics from NMR by molecular dynamics simulations, J. Am. Chem. Soc., 129, 14146-14147 (2007) [read online]
  • Snyder, D.A.; Xu, Y.; Yang, D.; Bruschweiler, R., Resolution-Enhanced 4D 15N/13C NOESY Protein NMR Spectroscopy by Application of the Covariance Transform, J. Am. Chem. Soc., 129, 14126-14127 (2007) [read online]
  • Snyder, D.A.; Zhang, F. and Bruschweiler, R., Covariance NMR in higher dimensions: application to 4D NOESY spectroscopy of proteins, J. Biomol. NMR, 39, 165-175 (2007) [read online]
  • Yang, W.; Nymeyer, H.; Zhou, H.-X.; Berg, B. and Brüschweiler, R., Quantitative computer simulations of biomolecules: A snapshot, J. Comput. Chem., 29, 668-672 (2007) [read online]
  • Zhang, F. and Bruschweiler, R., Robust deconvolution of complex mixtures by covariance TOCSY spectroscopy, Angew. Chem. Int. Ed., 46 (15), 2639-42 (2007) [read online]
  • Zhang, F.; Dossey, A.T.; Zachariah, C.; Edison, A.S. and Bruschweiler, R., Strategy for automated analysis of dynamic metabolic mixtures by NMR. Application to an insect venom., Anal. Chem., 79 (20), 7748-52 (2007) [read online]
    Presentations, Posters & Abstracts
  • Chen, Y.; Zhang, F.; Bermer, W.; Snyder, D.; Gan, Z.; Bruschweiler-Li, L. and Brüschweiler, R., Quantitative Covariance NMR with Minimal Datasets and Regularization, 48th ENC, Daytona Beach, FL, April 22-27 (2007)
  • Johnson, E.; Bruschweiler-Li, L.; Hilge, M.; Vuister, G.W. and Brüschweiler, R., Order-to-Disorder Transition of Na+/Ca2+ Exchanger, 48th ENC Conf., Daytona Beach, FL, April 22-27 (2007)
  • Showalter, S.A.; Bruschweiler-Li, L.; Zhang, F. and Brüschweiler, R., Dynamics of the N-terminal Domain of Human MDM2 Protein Free and Bound to a p53 Peptide, 48th ENC, Daytona Beach, FL, April 22-27 (2007)
  • Snyder, D.A.; Zhang, F. and Brüschweiler, R., Resolution Enhancement of 4D NOESY Data via Covariance Processing and Regularization, ENC, Daytona Beach, FL, April 22-28 (2007) [read online]
  • Zhang, F.; Brüschweiler, R.; Kaplan, F.; Zachariah, C.; Sippel, K.; Dossey, A.T. and Edison, A.S., NMR and Mixtures: New Developments for Natural Products and Metabolomics, 48th ENC, Daytona Beach, FL, April 22-27 (2007)

2006 Publications & Scientific Activities

    Peer-Reviewed Publications
  • Bouvignies, G.; Markwick, P.; Bruschweiler, R. and Blackledge, M., Simultaneous determination of protein backbone structure and dynamics from residual dipolar couplings, J. Am. Chem. Soc., 128 (47), 15100-15101 (2006) [read online]
  • Chen, Y.; Zhang, F.; Bermel, W. and Brüschweiler, R., Enhanced Covariance Spectroscopy From Minimal Datasets, J. Am. Chem. Soc., 128, 5522 (2006) [read online]
  • Ming, D. and Bruschweiler, R., Reorientational contact-weighted elastic network model for the prediction of protein dynamics: comparison with NMR relaxation, Biophysical J., 90, 3382 (2006) [read online]
  • Yang, M.F.; Yordanov, B.; Levy, Y.; Bruschweiler, R. and Huo, S.H., The sequence-dependent unfolding pathway plays a critical role in the amyloidogenicity of transthyretin, Biochemistry, 45 (39), 11992 (2006) [read online]
    Presentations, Posters & Abstracts
  • Chen, Y.; Zhang, F.; Bermel, W. and Brüschweiler, R., Enhanced Covariance NMR From Minimal Datasets, 35th Southeastern Magnetic Resonance Conf.,, Gainesville, FL, November 3-5 (2006); Published in J. Am. Chem. Soc., 128 (2006)
  • Johnson, E. and Brüschweiler, R., MD Simulations of the NMR Order Parameter at Multiple Temperatures, Gordon Research Conf.: Computational Aspects of Biomolecular NMR, Aussois, France, September 24-29 (2006)
  • Johnson, E.; Bruschweiler-Li, L.; Hilge, M.; Vuister, G. and Brüschweiler, R., Conformational Dynamics of the Na+/Ca2+ Exchanger, 35th Southeastern Magnetic Resonance Conf., Gainesville, FL, November 3-5 (2006)
  • Showalter, S.A.; Zhang, F.; Johnson, E.; Bruschweiler-Li, L. and Brüschweiler, R., Practical Aspects of Protein 15N Spin Relaxation Measurement at High Field, 35th Southeastern Magnetic Resonance Conf., Gainesville, FL, November 3-5 (2006)
  • Snyder, D.A. and Brüschweiler, R., Spectral Graph Theory and Application of Covariance Spectroscopy to NOESY Spectra, Southeastern Magnetic Resonance Conf., Gainesville, FL, November 3-5 (2006)

2005 Publications & Scientific Activities

    Peer-Reviewed Publications
  • Bouvignies, G.; Bernado, P.; Meier, S.; Cho, K.; Grzesiek, S.; Bruschweiler, R. and Blackledge, M., Identification of slow correlated motions in proteins using residual dipolar and hydrogen-bond scalar couplings, P. Natl. Acad. Sci. U.S.A., 102 (39), 13885-13890 (2005)
  • Fu, R.; Brey, W.W.; Shetty, K.; Gor'kov, P.; Saha, S.; Long, J.R.; Grant, S.C.; Chekmenev, E.Y.; Hu, J.; Gan, Z.; Sharma, M.; Zhang, F.; Logan, T.M.; Bruschweiler, R.; Edison, A.; Blue, A.; Dixon, I.; Markiewicz, W.D. and Cross, T.A., Ultra-Wide Bore 900 MHz High-Resolution NMR at the National High Magnetic Field Laboratory, J. Magn. Reson., 177, 1-8 (2005) [read online]
  • Yang, M.F.; Lei, M.; Brüschweiler, R. and Huo, S.H., Initial conformational changes of human transthyretin under partially denaturing conditions, Biophysical J., 89 (1), 433-443 (2005)
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