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900 MHz, Ultra-Wide Bore 105 mm NMR Magnet

Intro

Our ultra-wide bore 900 MHz NMR magnet (105 mm) was designed and built by the NHMFL's own Magnet Science and Technology department.  The magnet reached its full field of 21.1 Tesla on July 21, 2004, without incurring any training quenches.  Regular user operations started on August 1, 2005.  Since then, research proposals for the time on this instrument are accepted from interested scientists worldwide in all three areas of NMR: solid state, solution and imaging. 

An article on the magnet construction is available as a screen optimized (321 Kb) or print optimized (4.4 Mb) PDF files.

Applying for Instrument Time

We encourage potential users to apply for time on this 900 MHz instrument.  Research proposals for the instrument time should be submitted to Dr. R. Fu in accordance with the steps outlined here.  Experimental time is usually alloted prior to the start of each month.

Application Demos

  • TROSY spectra of M2 protein
  • Chemical shift correlated spectrum of a 15N-Acetyl-Valine crystal
  • Improved CPMAS resolution and homonuclear dipolar recoupling
  • 17O NMR spectroscopy of gramicidin and peptides using 900 MHz BB probe
  • Fixed mouse brain images from the 900 MHz scanner
  • First in-vivo mouse brain images from the 900 MHz scanner
  • High resolution PRESS localized spectroscopy using MRI

    Specs

  • Designation: Solid State NMR, Solution NMR, and Imaging
  • Location: Tallahassee
  • Field: 21.1 Tesla
  • Bore size: 105 mm
  • Distance to COF from RT shims flange: 1542 mm
  • Magnet Drift 525 Hz/hr, stabilized by current injection
  • Residual drift after stabilization is less than 10 Hz/hr
  • Outer (89 mm ID) RT shims by Resonance Research
  • Inner 26-channel Bruker RT shims for solution applications
  • 4-channel Bruker Avance 900 MHz console
  • Built-in VT controller by Bruker
  • 1000/300 W 6-365 MHz linear amplifier
  • 1000/150 W 700-900 MHz linear amplifier
  • Two 500 W 6-365 MHz linear amplifiers

    Commercial Probes

  • Bruker 3.2 mm 1H—13C—15N CPMAS probe, VT
  • Bruker micro2.5 MRI probe with 2.5, 5, 10, and 30 mm 1H coils
  • Bruker 5 mm 1H{13C,15N} solution probe with 3-axis gradients, VT

    NHMFL probes developed in-house

  • 3.2mm MAS 1H—X transmission line probe, expanded temperature range
  • Low-E 1H—X static probe for biological solids, flat and bicelle sample coils, biological VT
  • 1H—X transmission line probe, interchangeable static coils, biological VT

    Full Time Schedule [Older schedule]

    Dates PI Submitter Collaborators Project/Experiment Title
    12/22/11 - 01/04/12  Tatyana Polenova
    (University of Delaware)
     Tatyana Polenova William Brey
    Andrew Butterworth
    Zhehong Gan
    Yun Han
    Guangjin Hou
    Ivan Hung
    Sivakumar Paramasivam
    Tatyana Polenova
    Tatyana Polenova
    Christopher Suiter
    Solid-State NMR Structural and Dynamics Studies of HIV-1 Pro...
    3D experiments for resonance assignments of CA tubular assem...

    01/05/12 - 01/08/12  Samuel Grant
    (FSU & NHMFL)
     Jens Rosenberg Fabian Calixto Bejarano
    Ali Darkazalli
    Samuel Grant
    Cathy Levenson
    Teng Ma
    Chris Ridel
    Jens Rosenberg
    Jens Rosenberg
    Katelyn Sellgren
    Geoffrey Strouse
    In vivo tracking of exogenous and endogenous stem cells asso...
    in vivo stroke MRI with MSC injection

    01/09/12 - 01/11/12  Naresh Dalal
    (Florida St. University)
     Sneha Dugar Naresh Dalal
    Sneha Dugar
    Riqiang Fu
    Probing the origin of unexpected splitting in 31P CP-MAS of ...
    Probing the origin of unexpected splitting in 31P CP-MAS of ...

    01/12/12 - 01/15/12  Samuel Grant
    (FSU & NHMFL)
     Jens Rosenberg Fabian Calixto Bejarano
    Ali Darkazalli
    Samuel Grant
    Cathy Levenson
    Teng Ma
    Chris Ridel
    Jens Rosenberg
    Jens Rosenberg
    Katelyn Sellgren
    Geoffrey Strouse
    In vivo tracking of exogenous and endogenous stem cells asso...
    in vivo stroke MRI with MSC injection

    01/16/12 - 01/20/12  Chunyu Wang
    (Rensselaer Polytechnic Institute)
     Chunyu Wang Myriam Cotten
    Riqiang Fu
    Chunyu Wang
    Chunyu Wang
    NMR Studies of Aligned Multiply 15N-Labeled Transmembrane Do...
    NMR Studies of Aligned Multiply 15N-Labeled Transmembrane Do...

    01/21/12 - 01/22/12  Samuel Grant
    (FSU & NHMFL)
     Jens Rosenberg Fabian Calixto Bejarano
    Ali Darkazalli
    Samuel Grant
    Cathy Levenson
    Teng Ma
    Chris Ridel
    Jens Rosenberg
    Jens Rosenberg
    Katelyn Sellgren
    Geoffrey Strouse
    In vivo tracking of exogenous and endogenous stem cells asso...
    in vivo stroke MRI with MSC injection

    01/23/12 - 01/27/12  Tim Cross
    (FSU)
     Dylan Murray Tim Cross
    Jay Griffin
    Dylan Murray
    Dylan Murray
    Structure-Function Studies of Nucleotide Hydrolysis in a Mem...
    M. tuberculosis protein Rv1861 in aligned lipid bilayers

    01/28/12 - 01/29/12  Samuel Grant
    (FSU & NHMFL)
     Jose Muniz Barbara Beck
    William Brey
    Malathy Elumalai
    Samuel Grant
    Ihssan Masad
    Jose Muniz
    Jose Muniz
    Quadrature Surface and Array Coils for In Vivo Imaging and R...
    Array coil testing

    01/30/12 - 02/01/12  Chunyu Wang
    (Rensselaer Polytechnic Institute)
     Chunyu Wang Myriam Cotten
    Riqiang Fu
    Chunyu Wang
    Chunyu Wang
    NMR Studies of Aligned Multiply 15N-Labeled Transmembrane Do...
    NMR studies of a transmembrane protein involved in neurodege...

    02/02/12 - 02/12/12  Tatyana Polenova
    (University of Delaware)
     Tatyana Polenova William Brey
    Zhehong Gan
    Yun Han
    Guangjin Hou
    Ivan Hung
    Sivakumar Paramasivam
    Tatyana Polenova
    Tatyana Polenova
    Christopher Suiter
    Solid-State NMR Structural and Dynamics Studies of HIV-1 Pro...
    3D NCACX and NCOCX
    3D H-N and/or H-C dipolar lineshape...

    02/13/12  Victor Schepkin
    (NHMFL)
     Victor Schepkin William Brey
    Fabian Calixto Bejarano
    Malathy Elumalai
    Petr Gor'kov
    Cathy Levenson
    Thomas Morgan
    Victor Schepkin
    Victor Schepkin
    IN VIVO CHLORINE-35 MRI IN RODENT BRAIN
    In chlorine MRI with ZTE pulse sequence

    02/14/12  Samuel Grant
    (FSU & NHMFL)
     Jens Rosenberg Fabian Calixto Bejarano
    Ali Darkazalli
    Samuel Grant
    Cathy Levenson
    Teng Ma
    Chris Ridel
    Jens Rosenberg
    Jens Rosenberg
    Katelyn Sellgren
    Geoffrey Strouse
    In vivo tracking of exogenous and endogenous stem cells asso...
    in vivo stroke MRI with MSC injection

    02/15/12  Karunya Kandimalla
    (Florida A&M University)
     Jens Rosenberg Samuel Grant
    Kristen Jaruszewski
    Karunya Kandimalla
    Joseph Poduslo
    Jens Rosenberg
    Jens Rosenberg
    Development of Theranostic Nanovehicle to Target Toxic Amylo...
    Ex-vivo imaging of Alzheimer's disease transgenic mouse brai...

    02/16/12  Samuel Grant
    (FSU & NHMFL)
     Jens Rosenberg Fabian Calixto Bejarano
    Ali Darkazalli
    Samuel Grant
    Cathy Levenson
    Teng Ma
    Chris Ridel
    Jens Rosenberg
    Jens Rosenberg
    Katelyn Sellgren
    Geoffrey Strouse
    In vivo tracking of exogenous and endogenous stem cells asso...
    in vivo stroke MRI with MSC injection

    02/17/12 - 02/21/12  Tim Cross
    (FSU)
     Dylan Murray Tim Cross
    Jay Griffin
    Dylan Murray
    Dylan Murray
    Structure-Function Studies of Nucleotide Hydrolysis in a Mem...
    Magic angle spinning measurement of interhelical distances f...

    02/22/12 - 02/23/12  Samuel Grant
    (FSU & NHMFL)
     Jens Rosenberg Fabian Calixto Bejarano
    Ali Darkazalli
    Samuel Grant
    Cathy Levenson
    Teng Ma
    Chris Ridel
    Jens Rosenberg
    Jens Rosenberg
    Katelyn Sellgren
    Geoffrey Strouse
    In vivo tracking of exogenous and endogenous stem cells asso...
    in vivo stroke MRI with MSC injection

    02/24/12  Victor Schepkin
    (NHMFL)
     Victor Schepkin William Brey
    Fabian Calixto Bejarano
    Malathy Elumalai
    Petr Gor'kov
    Cathy Levenson
    Thomas Morgan
    Victor Schepkin
    Victor Schepkin
    IN VIVO CHLORINE-35 MRI IN RODENT BRAIN
    In chlorine MRI with ZTE pulse sequence

    02/25/12 - 02/27/12  Andrew Kiruluta
    (Harvard University)
     Samuel Grant Samuel Grant
    Samuel Grant
    Andrew Kiruluta
    Jose Muniz
    Alexey Tonyushkin
    MRI in the Far Field: Holographic Interferometry & Spatial E...
    Waveguide diameter testing




    02/28/12  Zhehong Gan
    (FSU)
     Ivan Hung William Brey
    Zhehong Gan
    Petr Gor'kov
    Ivan Hung
    Ivan Hung
    Development of methods and probes for solid-state NMR of bio...
    field ramp and 2H lock tests

    02/29/12 - 03/02/12  Naresh Dalal
    (Florida St. University)
     Sneha Dugar Naresh Dalal
    Sneha Dugar
    Riqiang Fu
    Probing the origin of unexpected splitting in 31P CP-MAS of ...
    Probing the origin of unexpected splitting in 31P CP-MAS of ...

     03/03/12 - Available -