NMR Program - Facilities

Intro

Our ultra-wide bore 900 MHz NMR magnet (105 mm) was designed and built by the NHMFL's own Magnet Science and Technology department. The magnet reached its full field of 21.1 Tesla on July 21, 2004, without incurring any training quenches. Regular user operations started on August 1, 2005. Since then, research proposals for the time on this instrument are accepted from interested scientists worldwide in all three areas of NMR: solid state, solution and imaging.

An article on the magnet construction is available as a screen optimized (321 Kb) or print optimized (4.4 Mb) PDF files.

Applying for Instrument Time

We encourage potential users to apply for time on this 900 MHz instrument. Research proposals for the instrument time should be submitted to Dr. R. Fu in accordance with the steps outlined here. Experimental time is usually alloted prior to the start of each month.

Application Demos

TROSY spectra of M2 protein

Chemical shift correlated spectrum of a ¹⁵N-Acetyl-Valine crystal

Improved CPMAS resolution and homonuclear dipolar recoupling

¹⁷O NMR spectroscopy of gramicidin and peptides using 900 MHz BB probe

Fixed mouse brain images from the 900 MHz scanner

First in-vivo mouse brain images from the 900 MHz scanner

High resolution PRESS localized spectroscopy using MRI

Specs

Designation: Solid State NMR, Solution NMR, and Imaging

Location: Tallahassee

Field: 21.1 Tesla

Bore size: 105 mm

Distance to COF from RT shims flange: 1542 mm

Magnet Drift 525 Hz/hr, stabilized by current injection

Residual drift after stabilization is less than 10 Hz/hr

Outer (89 mm ID) RT shims by Resonance Research

Inner 26-channel Bruker RT shims for solution applications

4-channel Bruker Avance 900 MHz console

Built-in VT controller by Bruker

1000/300 W 6-365 MHz linear amplifier

1000/150 W 700-900 MHz linear amplifier

Two 500 W 6-365 MHz linear amplifiers

Commercial Probes

Bruker 3.2 mm ¹H—¹³C—¹⁵N CPMAS probe, VT

Bruker micro2.5 MRI probe with 2.5, 5, 10, and 30 mm ¹H coils

Bruker 5 mm ¹H{¹³C,¹⁵N} solution probe with 3-axis gradients, VT

NHMFL probes developed in-house

3.2mm MAS ¹H—X transmission line probe, expanded temperature range

Low-E ¹H—X static probe for biological solids, flat and bicelle sample coils, biological VT

¹H—X transmission line probe, interchangeable static coils, biological VT

Full Time Schedule

[Older schedule]

Dates PI Submitter Collaborators Project/Experiment Title

01/02/10 - 01/07/10 Unused -

01/08/10 - 01/10/10 Peter Gorkov
(NHMFL) Samuel Grant William Brey
Peter Gorkov
Samuel Grant
Samuel Grant
Ihssan Masad The development of a novel sliding ring coil for 900 MHz hig...
The development of a novel sliding ring coil for 900 MHz hig...

01/11/10 - 01/17/10 Tim Cross
(FSU) Sorin Luca Tim Cross
Riqiang Fu
Sorin Luca Structure of full-length M2 membrane protein reconstituted i...
Structure and dynamics of M2 in DMPC/DMPG bilayers as a func...

01/18/10 - 01/19/10 Peter Gorkov
(NHMFL) Chunqi Qian William Brey
Peter Gorkov
Samuel Grant
Ihssan Masad
Chunqi Qian The development of a novel sliding ring coil for 900 MHz hig...
The development of a novel sliding ring coil for 900 MHz hig...

01/20/10 Victor Schepkin
(NHMFL) Victor Schepkin William Brey
Thomas Chenevert
John Cidlowski
Peter Gorkov
Cathy Levenson
Brian Ross
Victor Schepkin
Victor Schepkin Sodium and Diffusion MRI of Rodent Glioma Therapy
Sodium and ADC responses during BCNU resistant glioma therap...

01/21/10 - 01/25/10 Samuel Grant
(FSU & NHMFL) Samuel Grant Samuel Grant
Samuel Grant
Chris Ridel
Jens Rosenberg
Geoffrey Strouse High Field Contrast Agent Development: Qdot nanoparticles co...
T1, T2 and T2* measurements of labeled Bv2 cells: Fe vs Dy

01/26/10 - 01/29/10 Samuel Grant
(FSU & NHMFL) Samuel Grant Susanne Cappendijk
Parastou Foroutan
Samuel Grant
Samuel Grant Neurodegeneration Following MDMA Exposure in the Adult Male ...
MRS

01/30/10 - 02/07/10 Victor Schepkin
(NHMFL) Victor Schepkin William Brey
Thomas Chenevert
John Cidlowski
Peter Gorkov
Cathy Levenson
Brian Ross
Victor Schepkin
Victor Schepkin Sodium and Diffusion MRI of Rodent Glioma Therapy
Sodium and ADC responses during BCNU resistant glioma therap...

02/08/10 - 02/11/10 Mark Henkleman
(Hospital for Sick Children) Samuel Grant Samuel Grant
Samuel Grant
Mark Henkleman
Jason Lerch
John Sled HIGH FIELD IMAGING OF MOUSE BRAIN AND EMBRYO
3D anatomical imaging

02/12/10 - 02/14/10 Samuel Grant
(FSU & NHMFL) Samuel Grant Samuel Grant
Cathy Levenson
Jens Rosenberg
Geoffrey Strouse In vivo tracking of exogenous and endogenous labeled cells a...
In vivo tracking of exogenous and endogenous labeled cells a...

02/15/10 - 02/21/10 Tim Cross
(FSU) Sorin Luca Riqiang Fu
Sorin Luca
Dylan Murray Structure of full-length M2 membrane protein reconstituted i...
NMR studies of uniformly [13C,15N]-labeled M2 channel at dif...

02/22/10 - 02/23/10 Naresh Dalal
(Florida St. University) Sneha Dugar Sneha Dugar
Riqiang Fu Detection of ethyl group orientation in petroporphyrins by s...
Detection of ethyl group orientation in petroporphyrins by s...

02/24/10 Victor Schepkin
(NHMFL) Victor Schepkin William Brey
Thomas Chenevert
John Cidlowski
Peter Gorkov
Cathy Levenson
Brian Ross
Victor Schepkin
Victor Schepkin Sodium and Diffusion MRI of Rodent Glioma Therapy
Sodium and ADC responses during BCNU resistant glioma therap...

02/25/10 - 02/28/10 Samuel Grant
(FSU & NHMFL) Samuel Grant Parastou Foroutan
Samuel Grant
Katherine Schweitzer
Zbigniew Wszolek A Novel Approach to Dementia: High Resolution 1H MRI of Post...
Pathological 3D imaging

03/01/10 - Available -