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Samuel Grant (UF), Kiran Shetty (NHMFL)
Coronal images in the first Figure were acquired from an excised, perfusion-fixed C57BL/6J
mouse brain at 21.1T. Using a multi-slice gradient-recall echo sequence
acquired in 10 minutes, a resolution of 40x40x250 microns was achieved using
a 10-mm linear birdcage coil. Clockwise from upper left, the images display
increasing T2* weighting with TEs increasing from 4.5 ms to 24.5 ms. The
stunning increase in tissue contrast with increasing T2* weighting is not
significantly diminished by the loss in signal-to-noise ratio. Various
anatomical features can be observed in high contrast. These structures
include large vasculature in the cortex, fibers of the caudate and several
layers of the hippocampus. Because of the high magnetic field utilized,
these images appear to provide higher contrast than similar T2 weighted
images without suffering drastically from susceptibility-induced image
artifacts.
True three-dimensional images below were acquired from separate excised,
perfusion-fixed C57BL/6J mouse brain at 21.1T. Using a 3D gradient-recall
echo sequence acquired in 29 hours, resolution of 18x18x35 microns was achieved using a 10-mm
linear birdcage coil. Clockwise from upper left, the images display
increasing T2* weighting with TEs increasing from 4.5 ms to 24.5 ms. Various
anatomical features can be observed at high spatial resolutions, including
the cerebellum (possibly including granular cell layers), olfactory bulbs,
hippocampus, fimbria, large vasculature in the cortex, fibers of the caudate
and hippocampus. Fibers and bundles within the brain stem are readily evident as well as improved
enhancement of cortical layering.
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